Research Interest in Our Lab
It is becoming evident that microbiota can directly signal to the host by generating bioactive metabolites, which would contribute to the development (i.e., imidazole propionate) or amelioration of metabolic diseases (i.e., short-chain fatty acids). In our lab, we aim to identify therapeutics for metabolic diseases including diabetes and cancer based on mechanistic understanding of the role of microbial metabolites. In addition, we will investigate inter-individual variations or failure in drug response in the context of microbial metabolite milieu by using organoids as a model system.
1. Mechanistic Understanding of the Impacts of Microbial Metabolites on Personalized Responses to Metabolic Interventions
2. Understanding the Impacts of Microbial Regulation of Small Intestine in Host Metabolism by Using Intestinal Organoids
3. Development of Personalized POST-Biotics based on Microbial Metabolites
Better and Safer Therapeutics for Metabolic Diseases Based on Mechanistic Understanding of the Role of Microbial Metabolites
