PUBLICATIONS
Microbiota and Microbial metabolite research
1. Park H#, Park NY#, Koh A*. Scarring the early-life microbiome: its potential life-long effects on human health and diseases. BMB Rep. 2023 Sep;56(9):469-481. doi: 10.5483/BMBRep.2023-0114. (*Corresponding author; # Equal contribution)
2. Kim HS, Keum HL, Chung IY, Nattkemper L, Head C, Koh A, Sul WJ, Pastar I, Yosipovitch G. Characterization of a Perturbed Skin Microbiome in Prurigo Nodularis and Lichen Simplex Chronicus. J Invest Dermatol. 2023 Apr 10;S0022-202X(23)01959-0. (IF 7.590, JCR rank 3.76%, rank #4 in Dermatology)
3. Park NY, Koh A*. From the Dish to the Real World: Modeling Interactions between the Gut and Microorganisms in Gut Organoids by Tailoring the Gut Milieu. Int J Stem Cells. 2022 Feb 28;15(1):70-84. *Corresponding author (IF 3.011)
4.Kim HS, Park MY, Yun NJ, Go HS, Kim MY, Seong JK, Lee M, Kang ES, Ghim J, Ryu SH, Zabel BA, Koh A, Bae YS. Targeting PLD2 in adipocytes augments adaptive thermogenesis by improving mitochondrial quality and quantity in mice. J Exp Med. 2022 Feb 7;219(2):e20211523. (IF 17.579, JCR rank 2.31%, rank #5 in MEDICINE, RESEARCH & EXPERIMENTAL)
5. Andersson L, Cinato M, Mardani I, Miljanovic A, Arif M, Koh A, Lindbom M, Laudette M, Bollano E, Omerovic E, Klevstig M, Henricsson M, Fogelstrand P, Swärd K, Ekstrand M, Levin M, Wikström J, Doran S, Hyötyläinen T, Sinisalu L, Orešič M, Tivesten Å, Adiels M, Bergo MO, Proia R, Mardinoglu A, Jeppsson A, Borén J, Levin MC. Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking. European Heart Journal. 2021 Jul 23:ehab412. (IF 29.983, JCR rank 1.06%)
6. Venskutonyte R, Koh A, Khan MT, Stenstrom O, Lundqvist A, Akke M, Backhed F, Lindkvist-Petersson K. Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production. Nature Communications. 2021 Mar 1;12(1):1347. (IF 14.919, JCR rank 4.79%)
7. Ryu G#, Kim H#, Koh A*. Approaching precision medicine by tailoring the microbiota. Mammalian Genome. 2021 Accepted. *Corresponding author; # Equal contribution (IF 2.957, JCR rank 56.29%)
8. Koh A*, Mannerås-Holm L, Yunn NO, Nilsson PM, Ryu SH, Molinaro A, Perkins R, Smith JG, Bäckhed F. Cell Metabolism. 2020. Published online. *First and Co-corresponding author. (IF 27.287, 1.72%, rank #3 in Endocrinology & Metabolism)
9. Koh A* and Backhed F. From association to causality: the role of the gut microbiota and its functional products on host metabolism. Molecular Cell. 2020 May; 78(4): 584-596. *First and Co-corresponding author. (IF. 17.97, 1.85%)
10. Molinaro A*, Koh A*, Wu H, Schoeler M, Faggi I, Carreras A, Hallén A, Bäckhed F, Caesar R. Hepatic expression of Lipopolysaccharide Binding Protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity. Mol Metab. 2020 Apr 16. *Co-first authors. (IF. 7.422, 8.714%, rank #13 in Endocrinology & Metabolism)
11. Koh A, Molinaro A, Stahlman M, Khan MT, Schmidt C, Manneras-Holm L, Wu H, Carreras A, Jeong H, Olofsson L, Bergh PO, Gerdes V, Hartstra A, Brauw M, Perkins R, Nieuwdorp M, Bergstrom G, Backhed F. Microbially produced imidazole propionate impairs insulin signaling through mTORC1. Cell. 2018 Nov; 175 (4): 947-961. (IF. 38.637, 0.168%, rank #1 in Biochemistry & Molecular biology)
- Research Highlight in Nature Reviews Endocrinology (2018), Editor’s Choice in Science (2018), News & Comment in Nature Reviews Drug Discovery (2018).
12. Koh A, Vadder DF, Kovatcheva-Datchary P, Bäckhed F. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. Cell. 2016 Jun; 165 (2): 1332-1345. (IF. 38.637, 0.168%, rank #1 in Biochemistry & Molecular biology)
13. Kim IH, Kim IJ, Wen Y, Park NY, Park J, Lee KW, Koh A, Lee JH, Koo SH, Kim KS. Vibrio vulnificus Secretes an Insulin-degrading Enzyme That Promotes Bacterial Proliferation in Vivo. J Biol Chem. 2015 Jul; 24(290): 18708-18720.
Signal Transduction research
1. Molinaro A, Caesar R, L'homme L, Koh A, Ståhlman M, Staels B, Bäckhed F. Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding. Mol Metab. 2019 Mar; 9
2. Kim E, Kim DH, Singaram I, Jeong H, Koh A, Lee J, Cho W, Ryu SH. Cellular phosphatase activity of C1-Ten/Tensin2 is controlled by Phosphatidylinositol-3,4,5-triphosphate binding through the C1-Ten/Tensin2 SH2 domain. Cell Signal. 2018 Aug; 7 (51): 130-138
3. Jeong H, Koh A, Lee J, Park D, Lee JO, Lee MN, Jo KJ, Tran HNK, Kim E, Min BS, Kim HS, Berggren PO, Ryu SH. Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways. Sci Rep. 2017 Dec; 7 (1): 177777.
4. Lee J, Koh A, Jeong H, Kim E, Ha TS, Saleem MA, Ryu SH. C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation. Sci Rep. 2017 Sep; 7(1): 12346.
5. Park D, Jeong H, Lee MN, Koh A, Kwon O, Yang YR, Noh J, Suh PG, Park H, Ryu SH. Resveratol induces autophagy by directly inhibiting mTOR through ATP competition. Sci Rep. 2016 Feb; 23 (6): 21772
6. Yang YR, Jang HJ, Choi SS, Lee YH, Lee GH, Seo YK, Choi JH, Park D, Koh A, Kim IS, Lee H, Ryu SH, Suh PG. Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga +/- mice. Diabetologia. 2015 Dec; 58 (12): 2867-2876.
7. Yunn NO, Koh A, Han S, Lim JH, Park S, Lee J, Kim E, Jang SK, Berggren PO, Ryu SH. Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation. Nucleic Acids Res. 2015 Aug.
8. Song P, Kwon Y, Yea K, Moon HY, Yoon JH, Ghim J, Hyun H, Kim D, Koh A, Berggren PO, Suh PG, Ryu SH. Apolipoprotein a1 increases mitochondrial biogenesis through AMP-activated protein kinase. Cell Signal. 2015 Sep; 27(9): 1873-1881.
9. Koh A, Park D, Jeong H, Lee J, Lee MN, Suh PG, Ryu SH. Regulation of C1-Ten protein tyrosine phosphatase by p62/SQSTM1-mediated sequestration and degradation. Cell Signal. 2014 Nov; 26(11): 2470-2480.
10. Park D, Lee MN, Jeong H, Koh A, Yang YR, Suh PG, Ryu SH. Parkin ubiquitinates mTOR to regulate mTORC1 activity under mitochondrial stress. Cell Signal. 2014 Jul; 26(10): 2122-2130.
11. Koh A, Lee MN, Yang YR, Jeong H, Ghim J, Noh J, Kim J, Ryu D, Park S, Song P, Koo SH, Leslie NR, Berggren PO, Choi JH, Suh PG, Ryu SH. C1-Ten is a protein tyrosine phosphatase of IRS-1, regulating IRS-1 stability and muscle atrophy. Mol. Cell. Biol. 2013 Apr; 33(8): 1608-1620.
12. Lee MN, Koh A, Park D, Jang JH, Kwak D, Jeon H, Kim J, Choi EJ, Jeong H, Suh PG, Ryu SH. Deacetylated αβ-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading. Cell Signal. 2013 Feb; 25(2): 539-551.
13. Yang YR, Song M, Ho Lee H, Jeon Y, Choi EJ, Jang HJ, Moon HY, Byun HY, Kim HK, Kim DH, Lee MN, Koh A, Ghim J, Choi JH, Lee-Kwon W, Kim KT, Sung Ho Ryu SH, Suh PG. O-GlcNAcase is essential for embryonic development and maintenance of genomic stability. Aging Cell. 2012 Jun; 11(3): 439-448.
14. Lee MN, Ha SH, Kim J, Koh A, Lee CS, Kim JH, Jeon H, Kim DH, Suh PG, Ryu SH. Glycolytic flux signals to mTOR through GAPDH-mediated regulation of Rheb. Mol. Cell. Biol. 2009 Jul; 29(14): 3991-4001.